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apalutamide will minimize the level or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with drugs which have been CYP2C19 substrates can lead to lower exposure to those prescription drugs.C: Use with warning if Advantages outweigh risks